Normal retina thickness11/8/2023 Myopia and incipient cataract not affecting the quality of the OCT images were no reason for exclusion of the individual. The Medical Ethics Committee of the Beijing Tongren Hospital approved the study protocol, and all participants gave informed written consent.Ĭriteria for inclusion into the present study were the absence of systematic diseases such as arterial hypertension, hyperlipidemia, diabetes mellitus, manifest cardiovascular diseases, previous myocardial infarction, cerebral trauma and stroke, and the absence of ocular diseases such as glaucoma, diabetic retinopathy, status after cataract surgery, ocular trauma, retinal vascular occlusions, age-related macular degeneration, pigment epithelium detachment, retinal detachment, polypoidal choroidal vasculopathy and central serous chorioretinopathy. Among the study participants, 1633 individuals (47.1% 943 women) were from the rural region. The mean age was 64.6☙.8 years (median, 64 years range, 50-93 years). The study population consisted of 3468 (78.8%) individuals out of 4403 eligible individuals. The only eligibility criteria for inclusion into the study were an age of 50+ years and living in the study region. The population-based, cross-sectional Beijing Eye Study 2011 was carried out in 5 communities in the urban district of Haidian in the North of Central Beijing and in 3 communities in the village area of Yufa of the Daxing District in the South of Beijing. We therefore conducted the present study to measure the various retinal layers in a population-based investigation of healthy individuals. Limitations of these studies were their design as hospital-based investigations and the relatively small size of the study populations. After automated algorithms have recently been developed, the thickness of the middle and deep retinal layers has been determined in healthy eyes, eyes with glaucoma and in eyes after optic neuritis. In contrast, the thickness of the middle and deep retinal layers has usually not routinely been assessed. Besides the total retinal thickness, the thickness of the inner retinal layers, namely the retinal nerve fiber layer and the retinal ganglion cell layer, has routinely been measured for the diagnosis and follow-up examination of optic nerve diseases, in particular of glaucomatous optic neuropathy. The clinical introduction of optical coherence tomography (OCT), allowing the intravital non-invasive visualization of the various retinal layers with a spatial resolution of approximately 5 to 10 μm has markedly improved the possibilities in the diagnosis of retinal and optic nerve diseases. The associations between decreasing thickness of most retinal layers with older age and the correlation of a higher thickness of some retinal layers with male gender may clinically be taken into account. The inner plexiform layer was thicker, and the ganglion cell layer and inner nuclear layer were thinner, in the temporal areas than in the nasal areas, Conclusions The associations between the macular retinal layers thickness and axial length were not consistent. ![]() Men as compared to women had higher thickness measurements of the photoreceptor layer and outer nuclear layer in all areas, and of all layers between the retinal nerve fiber layer and inner nuclear layer in the parafoveal area (all P < 0.05). In multivariable analysis, the thickness of the foveola and of all retinal layers in the foveal, parafoveal and perifoveal region decreased with older age (all P < 0.05), except for the thickness of the parafoveal outer plexiform layer which increased with age. The study included 384 subjects (mean age:60.0 ± 8.0 years). Segmentation and measurement of the retinal layers was performed automatically in each of the horizontal scans. Using spectral-domain optical coherence tomographic images (Spectralis®, wavelength: 870 nm Heidelberg Engineering Co, Heidelberg, Germany), we measured the thickness of the macular retinal layers in participants of the population-based Beijing Eye Study without ocular diseases and without systematic diseases, such as arterial hypertension, hyperlipidemia, diabetes mellitus, cardiovascular diseases, previous myocardial infarction, cerebral trauma and stroke. Here we measured the thickness of the macular retinal layers in a population-based study group to assess the normative values and their associations. Diagnosis and follow-up of retinal diseases may be improved if the thickness of the various retinal layers, in addition to the total retinal thickness, is taken into account.
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